In response to a recent outbreak of the Sudan strain of the Ebola virus, Ugandan health authorities have commenced a clinical trial for a targeted vaccine.
The outbreak, which resulted in the death of a nurse on January 29, 2025, has prompted swift action to curb further transmission.
The iniitial case involved a 32-year-old nurse at Mulago National Referral Hospital in Kampala. She eited symptoms such as high fever, breathing difficulties, and unexplained bleeding, ultimately succumbing to multi-organ failure.
Following her death, health officials identified at least 234 contacts, including health workers and family members, who are now under monitoring.
The vaccine candidate, developed by the International AIDS Vaccine Initiative (IAVI), is beinginistered by the Makerere University Lung Institute in Kampala.
Approximately 2,460 doses have been allocated for the trial, which primarily targets health workend individuals who have been in contact with confirmed cases. The World Health Organization (WHO) is leading the ring vaccination trial, aiming to evaluatthe vaccine's effica in preventing the spread of the virus.
Unlike the Zastrain of Ebola, for which approved vaccines exist, there is currently no licensed vaccine for the Sudan strain.
The initiation of this trial marks a critical step in addressing this gap. Dr. Matshidiso Moeti, WHO's rica Director, emphaz the importance of this collaboration, stating that an effective vaccine would enhance protective measures against future outbreaks of this high-fatality dse.
The densely populated nature of Kampala, with its highly mobile population of approximately 4 million, poses significant lenges for containment efforts. Health authorities are urging the public to adhere to hygiene practices and social distancing measures to mitigate the spread of the virus.
As the trial progresses, health officiawill closely monitor participants for safety and efficacy outcomes. The data collected will be instrumental in determining the vaccine's potential for broader use in controlling the Sudan strain of Ebola, both in Uganda and in other regions at risk.
This initiative underscores the global health community's commitment to developing targeted interventions for Ebola and enhancing preparedness for future outbreaks.
Source. WHO
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